Gut Glucosinolate Metabolism and Isothiocyanate Production
نویسندگان
چکیده
منابع مشابه
Glucosinolate metabolism and its control.
Glucosinolates and their associated degradation products have long been recognized for their distinctive benefits to human nutrition and plant defense. Because most of the structural genes of glucosinolate metabolism have been identified and functionally characterized in Arabidopsis thaliana, current research increasingly focuses on questions related to the regulation of glucosinolate synthesis...
متن کاملMyrosinase-dependent and –independent formation and control of isothiocyanate products of glucosinolate hydrolysis
Brassicales contain a myrosinase enzyme that hydrolyzes glucosinolates to form toxic isothiocyanates (ITC), as a defense against bacteria, fungi, insects and herbivores including man. Low levels of ITC trigger a host defense system in mammals that protects them against chronic diseases. Because humans typically cook their brassica vegetables, destroying myrosinase, there is a great interest in ...
متن کاملSaxA-Mediated Isothiocyanate Metabolism in Phytopathogenic Pectobacteria.
Pectobacteria are devastating plant pathogens that infect a large variety of crops, including members of the family Brassicaceae. To infect cabbage crops, these plant pathogens need to overcome the plant's antibacterial defense mechanisms, where isothiocyanates are liberated by hydrolysis of glucosinolates. Here, we found that a Pectobacterium isolate from the gut of cabbage root fly larvae was...
متن کاملIdentification of Arabidopsis mutants with altered glucosinolate profiles based on isothiocyanate bioactivity
Glucosinolates are a diverse class of nitrogenand sulfur-containing secondary metabolites. They are rapidly hydrolyzed on tissue disruption to a number of biologically active compounds that are increasingly attracting interest as anticarcinogenic phytochemicals and crop protectants. Several glucosinolate-derived isothiocyanates are potent chemopreventive agents that favorably modulate carcinoge...
متن کاملXenobiotic Metabolism and Gut Microbiomes
Humans are exposed to numerous xenobiotics, a majority of which are in the form of pharmaceuticals. Apart from human enzymes, recent studies have indicated the role of the gut bacterial community (microbiome) in metabolizing xenobiotics. However, little is known about the contribution of the plethora of gut microbiome in xenobiotic metabolism. The present study reports the results of analyses o...
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ژورنال
عنوان ژورنال: Molecular Nutrition & Food Research
سال: 2018
ISSN: 1613-4125
DOI: 10.1002/mnfr.201700991